Right now I'm shooting a 40's era Remington 22 bolt-action (left hand bolt, cartridges go in a little pipe slung under the barrel) but with Winchester Wildcats (extra powder charge, brass jacketed lead bullet) I've dropped a coyote with it. Bullet tends to tumble when it hits, and not break up.

I want my granddad's .308 with the thumbhole stock. That's a nice gun for when it absolutely, positively does not need to enter your yard again.