Stevie Ray Vaughan -- Little Wing.
Another song that brings back all sorts of warm fuzzy feelings from the high school days, most vividly the senior kegger I was invited to when I was a junior in high school (35 kids in my high school, I bet most of you have more kids in your class!). Long story short, a couple of buddies from a neighboring town and I set up and jammed on blues rock most the night--lots of SRV and Jimi Hendrix. The guitarist, who sadly died in a one vehicle wreck in 2000, could flat out PLAY. He nailed Stevie's solo at the 3:20 mark--I recall closing my eyes while holding the groove down and getting goosebumps all over. AND HE WAS DOING THIS WITH A LES PAUL! No tremelo other than his hands and a smattering of pedals.
And since I've been on a bit of a Steve Vai kick...here's the same song from the Astoria: